SDH-Engine — Drug Repurposing for SDH-Deficient Diseases

This tool is for research exploration only. It is not a medical device and does not provide medical advice. Drug candidates, evidence scores, and AI-generated content are not clinical recommendations. Always consult your medical team before making any treatment decisions.

Drug Candidates

65 candidates mapped to SDH-deficient disease pathways

All (65)established (7)clinical trial (13)preclinical (13)theoretical (32)

Welireg

HIF-2α inhibitor

Hif Pseudohypoxia

FDA Approved1 trial

Sutent

Multi-kinase inhibitor (VEGFR/PDGFR/KIT)

Vegf SignalingMtor Pi3k Akt

GISTPPGL/PCCRCC

FDA Approved1 trial

Pan-FGFR inhibitor (FGFR1/2/3/4)

Fgfr SignalingEpigenetic Dysregulation

Temodar, Temodal

Alkylating agent

Epigenetic Dysregulation

FDA Approved1 trial

Avastin

Anti-VEGF monoclonal antibody

Vegf SignalingHif Pseudohypoxia

Tazverik

EZH2 inhibitor (PRC2 inhibitor)

Epigenetic Dysregulation

FDA Approved1 trial

Dacogen

DNA methyltransferase inhibitor (hypomethylating agent)

Epigenetic Dysregulation

Lynparza

PARP inhibitor (PARP1/2)

Sdh Driven HrdOxidative Stress Ros

FDA Approved1 trial

Cabometyx, Cometriq

Multi-kinase inhibitor (VEGFR2/MET/AXL/RET/KIT)

Hif Met Axl SignalingVegf Signaling

FDA Approved3 trials

CB-839

Glutaminase inhibitor

Glutamine Dependency

Stivarga

Multi-kinase inhibitor (VEGFR/KIT/PDGFR/FGFR/RAF)

Vegf SignalingMtor Pi3k AktFgfr Signaling

FDA Approved1 trial

Afinitor

mTOR inhibitor (rapalog)

FDA Approved1 trial

Vidaza

DNA methyltransferase inhibitor (hypomethylating agent)

Epigenetic Dysregulation

Pemazyre

Selective FGFR1/2/3 inhibitor

FDA Approved1 trial

Daporinad (FK866)

APO866

NAMPT inhibitor (NAD⁺ biosynthesis inhibitor)

Nad MetabolismOxidative Stress Ros

Zejula

PARP inhibitor (PARP1/2)

FDA Approved1 trial

Yttrium-90 SIRT

SIR-Spheres, TheraSphere

Liver-directed radioembolization

Hydroxychloroquine

Plaquenil

Autophagy inhibitor (lysosomal alkalinizer)

Autophagy Survival

FDA Approved2 trials

Balversa

Pan-FGFR inhibitor (FGFR1/2/3/4), FDA-approved

FDA Approved1 trial

Iobenguane I-131 (Azedra, ¹³¹I-MIBG)

Azedra

NET-targeted beta-particle radiopharmaceutical (¹³¹I-labeled guanethidine analog)

Mibg Net Targeted RadiationSdh Driven Hrd

Glucophage

Biguanide / AMPK activator

Mtor Pi3k AktOxidative Stress Ros

DENSPM (N1,N11-Diethylnorspermine)

Polyamine analogue / SSAT inducer

Polyamine MetabolismOxidative Stress Ros

TVB-2640

FASN inhibitor (fatty acid synthase inhibitor)

De Novo LipogenesisGlutamine Dependency

Lutetium-177 DOTATATE

Lutathera

Peptide receptor radionuclide therapy (PRRT) / SSTR2-targeted radioligand therapy

Sstr2 Somatostatin VulnerabilitySdh Driven Hrd

FDA Approved3 trials

OTX015, MK-8628

BET bromodomain inhibitor (pan-BRD2/3/4)

Epigenetic Dysregulation

AZD6738

ATR kinase inhibitor

Atrx Alt Replication Stress

Keytruda

Anti-PD-1 monoclonal antibody (checkpoint inhibitor)

Hif Pdl1 Checkpoint EvasionSuccinate Immune Evasion

FDA Approved2 trials

Truqap

Pan-AKT inhibitor (allosteric PH-domain binding; AKT1/2/3)

PPGL/PCCGISTRCC

FDA Approved1 trial

Ym155 (Sepantronium Bromide)

YM155, Sepantronium

Survivin (BIRC5) transcription inhibitor / IAP inhibitor

Hif Driven Survivin ApoptosisSdh Driven Hrd

TAK-228, MLN0128

Dual mTORC1/2 kinase inhibitor (active-site TOR inhibitor)

Farydak

Pan-HDAC inhibitor

Epigenetic Dysregulation

FDA Approved1 trial

MCT1 inhibitor (monocarboxylate transporter 1 inhibitor, SLC16A1)

Succinate Immune Evasion

TAK-924

NAE inhibitor (neddylation inhibitor, NEDD8-activating enzyme inhibitor)

POLQ inhibitor (DNA polymerase theta inhibitor)

Polq Tmej Backup RepairSdh Driven Hrd

Ibrance

CDK4/6 inhibitor

Cdkn2a Cdk46 Cell CycleEpigenetic Dysregulation

G-quadruplex DNA stabilizer

G4 Quadruplex Brcas LethalitySdh Driven Hrd

AZD7648

DNA-PKcs inhibitor (DNA-dependent protein kinase catalytic subunit inhibitor)

Nhej Dnapk Backup RepairSdh Driven Hrd

Idhifa

IDH2 inhibitor

Epigenetic Dysregulation

DUP-785, NSC 368390

DHODH inhibitor (dihydroorotate dehydrogenase inhibitor)

Pyrimidine Synthesis Vulnerability

[212Pb]VMT-α-NET

Alpha-particle SSTR2-targeted radioligand therapy (RLT)

Sstr2 Somatostatin VulnerabilitySdh Driven Hrd

LY2606368

CHK1/CHK2 kinase inhibitor

Chk1 Brcas Replication CheckpointSdh Driven Hrd

M3814

DNA-PK (DNA-PKcs/PRKDC) inhibitor

Nhej Dnapk Backup RepairSdh Driven Hrd

STA-9090

HSP90 inhibitor (non-ansamycin resorcinol-based)

Hsp90 Hif Client ChaperoneHif Pseudohypoxia

CDK9 inhibitor (selective P-TEFb kinase inhibitor)

Cdk9 Super Enhancer ElongationEpigenetic Dysregulation

Inobrodib

CBP/p300 bromodomain inhibitor

Cbp P300 Hat CoactivatorEpigenetic Dysregulation

[²¹¹At]MABG (Alpha-Particle MIBG)

NET-targeted alpha-particle radiopharmaceutical (²¹¹At-labeled guanethidine analog)

Mibg Net Targeted RadiationSdh Driven Hrd

RBS2418 (Uzaribat)

ENPP1 inhibitor

Cgas Sting Innate ImmuneSdh Driven Hrd

MLN8237

Aurora A kinase inhibitor (selective, oral)

Aurora Kinase Hif FeedbackHif Pseudohypoxia

Rytelo

Telomerase inhibitor (competitive TERT template antagonist)

Tert Telomerase Reactivation

FDA Approved1 trial

MK-1454

Cyclic dinucleotide STING agonist (intratumoral)

Cgas Sting Innate ImmuneSdh Driven Hrd

Eflornithine (DFMO)

Iwilfin, Ornidyl

ODC1 inhibitor (ornithine decarboxylase inhibitor / polyamine synthesis inhibitor)

Polyamine Metabolism

Nexletol, Nilemdo

ACLY inhibitor (ATP-citrate lyase inhibitor, prodrug)

Reductive CarboxylationGlutamine Dependency

MEDI9447

Anti-CD73 monoclonal antibody (immune checkpoint, adenosine pathway)

Hif Cd73 Adenosine ImmunosuppressionHif Pseudohypoxia

Dichloroacetate (DCA)

Pyruvate dehydrogenase kinase inhibitor

Hif PseudohypoxiaOxidative Stress Ros

INCB024360

IDO1 inhibitor (indoleamine 2,3-dioxygenase 1 inhibitor)

Succinate Immune Evasion

Aubagio

DHODH inhibitor (active metabolite of leflunomide; FDA-approved)

Pyrimidine Synthesis Vulnerability

FDA Approved1 trial

STA-4783

Copper ionophore

Cuproptosis Lipoylation MtfasDe Novo Lipogenesis

OSI-906

IGF1R/IR dual kinase inhibitor

Hif Igf2 Igf1r Growth SignalingHif Pseudohypoxia

AB928

Adenosine A2A/A2B receptor antagonist (dual; oral small molecule)

Hif Cd73 Adenosine ImmunosuppressionHif Pseudohypoxia

Hu5F9-G4

Anti-CD47 monoclonal antibody (macrophage phagocytosis-checkpoint inhibitor)

Hif Cd47 Phagocytosis EvasionHif Pseudohypoxia

AMD3100, Mozobil

CXCR4 chemokine receptor antagonist

Hif Cxcr4 Chemokine MetastasisHif Pseudohypoxia

FDA Approved1 trial

WBI-5111

Carbonic anhydrase IX/XII inhibitor (CA9/CA12 selective)

Hif Ca9 Ph RegulationHif Pseudohypoxia

Opdualag

LAG-3 checkpoint inhibitor (anti-LAG-3 monoclonal antibody)

Succinate Lag3 ExhaustionSuccinate Immune Evasion

FDA Approved1 trial

Yervoy

CTLA-4 checkpoint inhibitor (anti-CTLA-4 IgG1κ monoclonal antibody)

Ido1 Kynurenine Treg Ctla4Succinate Immune Evasion

FDA Approved1 trial

Ascorbic Acid (High-dose IV)

TET enzyme cofactor / α-KG-dependent dioxygenase activator

Epigenetic DysregulationOxidative Stress Ros