This tool is for research exploration only. It is not a medical device and does not provide medical advice. Drug candidates, evidence scores, and AI-generated content are not clinical recommendations. Always consult your medical team before making any treatment decisions.

Drug Candidates

13 candidates mapped to SDH-deficient disease pathways

All (38)established (6)clinical trial (5)preclinical (14)theoretical (13)
Niraparib

Zejula

theoretical

PARP inhibitor (PARP1/2)

Sdh Driven Hrd
All SDH tumors
Evidence Score
45
FDA Approved
Erdafitinib

Balversa

theoretical

Pan-FGFR inhibitor (FGFR1/2/3/4), FDA-approved

Fgfr Signaling
GIST
Evidence Score
42
FDA Approved
Birabresib

OTX015, MK-8628

theoretical

BET bromodomain inhibitor (pan-BRD2/3/4)

Epigenetic Dysregulation
GIST
Evidence Score
33
1 trial
Pembrolizumab

Keytruda

theoretical

Anti-PD-1 monoclonal antibody (checkpoint inhibitor)

Hif Pdl1 Checkpoint EvasionSuccinate Immune Evasion
All SDH tumors
Evidence Score
32
FDA Approved2 trials
Panobinostat

Farydak

theoretical

Pan-HDAC inhibitor

Epigenetic Dysregulation
All SDH tumors
Evidence Score
30
FDA Approved
Palbociclib

Ibrance

theoretical

CDK4/6 inhibitor

Cdkn2a Cdk46 Cell CycleEpigenetic Dysregulation
GIST
Evidence Score
30
FDA Approved
Enasidenib

Idhifa

theoretical

IDH2 inhibitor

Epigenetic Dysregulation
All SDH tumors
Evidence Score
28
FDA Approved
Brequinar

DUP-785, NSC 368390

theoretical

DHODH inhibitor (dihydroorotate dehydrogenase inhibitor)

Pyrimidine Synthesis Vulnerability
All SDH tumors
Evidence Score
28
1 trial
ART558
theoretical

POLQ inhibitor (DNA polymerase theta inhibitor)

Polq Tmej Backup RepairSdh Driven Hrd
All SDH tumors
Evidence Score
27
Eflornithine (DFMO)

Iwilfin, Ornidyl

theoretical

ODC1 inhibitor (ornithine decarboxylase inhibitor / polyamine synthesis inhibitor)

Polyamine Metabolism
PPGL/PCC
Evidence Score
23
FDA Approved
Epacadostat

INCB024360

theoretical

IDO1 inhibitor (indoleamine 2,3-dioxygenase 1 inhibitor)

Succinate Immune Evasion
PPGL/PCC
Evidence Score
22
1 trial
Teriflunomide

Aubagio

theoretical

DHODH inhibitor (active metabolite of leflunomide; FDA-approved)

Pyrimidine Synthesis Vulnerability
All SDH tumors
Evidence Score
22
FDA Approved1 trial
Ascorbic Acid (High-dose IV)
theoretical

TET enzyme cofactor / α-KG-dependent dioxygenase activator

Epigenetic DysregulationOxidative Stress Ros
PPGL/PCC
Evidence Score
18