SDH-Engine — Drug Repurposing for SDH-Deficient Diseases

This tool is for research exploration only. It is not a medical device and does not provide medical advice. Drug candidates, evidence scores, and AI-generated content are not clinical recommendations. Always consult your medical team before making any treatment decisions.

Drug Candidates

32 candidates mapped to SDH-deficient disease pathways

All (65)established (7)clinical trial (13)preclinical (13)theoretical (32)

Zejula

PARP inhibitor (PARP1/2)

FDA Approved1 trial

Balversa

Pan-FGFR inhibitor (FGFR1/2/3/4), FDA-approved

FDA Approved1 trial

OTX015, MK-8628

BET bromodomain inhibitor (pan-BRD2/3/4)

Epigenetic Dysregulation

Keytruda

Anti-PD-1 monoclonal antibody (checkpoint inhibitor)

Hif Pdl1 Checkpoint EvasionSuccinate Immune Evasion

FDA Approved2 trials

Truqap

Pan-AKT inhibitor (allosteric PH-domain binding; AKT1/2/3)

PPGL/PCCGISTRCC

FDA Approved1 trial

TAK-228, MLN0128

Dual mTORC1/2 kinase inhibitor (active-site TOR inhibitor)

Farydak

Pan-HDAC inhibitor

Epigenetic Dysregulation

FDA Approved1 trial

Ibrance

CDK4/6 inhibitor

Cdkn2a Cdk46 Cell CycleEpigenetic Dysregulation

AZD7648

DNA-PKcs inhibitor (DNA-dependent protein kinase catalytic subunit inhibitor)

Nhej Dnapk Backup RepairSdh Driven Hrd

Idhifa

IDH2 inhibitor

Epigenetic Dysregulation

DUP-785, NSC 368390

DHODH inhibitor (dihydroorotate dehydrogenase inhibitor)

Pyrimidine Synthesis Vulnerability

LY2606368

CHK1/CHK2 kinase inhibitor

Chk1 Brcas Replication CheckpointSdh Driven Hrd

M3814

DNA-PK (DNA-PKcs/PRKDC) inhibitor

Nhej Dnapk Backup RepairSdh Driven Hrd

STA-9090

HSP90 inhibitor (non-ansamycin resorcinol-based)

Hsp90 Hif Client ChaperoneHif Pseudohypoxia

CDK9 inhibitor (selective P-TEFb kinase inhibitor)

Cdk9 Super Enhancer ElongationEpigenetic Dysregulation

RBS2418 (Uzaribat)

ENPP1 inhibitor

Cgas Sting Innate ImmuneSdh Driven Hrd

MLN8237

Aurora A kinase inhibitor (selective, oral)

Aurora Kinase Hif FeedbackHif Pseudohypoxia

Rytelo

Telomerase inhibitor (competitive TERT template antagonist)

Tert Telomerase Reactivation

FDA Approved1 trial

MK-1454

Cyclic dinucleotide STING agonist (intratumoral)

Cgas Sting Innate ImmuneSdh Driven Hrd

Eflornithine (DFMO)

Iwilfin, Ornidyl

ODC1 inhibitor (ornithine decarboxylase inhibitor / polyamine synthesis inhibitor)

Polyamine Metabolism

Nexletol, Nilemdo

ACLY inhibitor (ATP-citrate lyase inhibitor, prodrug)

Reductive CarboxylationGlutamine Dependency

MEDI9447

Anti-CD73 monoclonal antibody (immune checkpoint, adenosine pathway)

Hif Cd73 Adenosine ImmunosuppressionHif Pseudohypoxia

Dichloroacetate (DCA)

Pyruvate dehydrogenase kinase inhibitor

Hif PseudohypoxiaOxidative Stress Ros

INCB024360

IDO1 inhibitor (indoleamine 2,3-dioxygenase 1 inhibitor)

Succinate Immune Evasion

Aubagio

DHODH inhibitor (active metabolite of leflunomide; FDA-approved)

Pyrimidine Synthesis Vulnerability

FDA Approved1 trial

STA-4783

Copper ionophore

Cuproptosis Lipoylation MtfasDe Novo Lipogenesis

OSI-906

IGF1R/IR dual kinase inhibitor

Hif Igf2 Igf1r Growth SignalingHif Pseudohypoxia

AMD3100, Mozobil

CXCR4 chemokine receptor antagonist

Hif Cxcr4 Chemokine MetastasisHif Pseudohypoxia

FDA Approved1 trial

WBI-5111

Carbonic anhydrase IX/XII inhibitor (CA9/CA12 selective)

Hif Ca9 Ph RegulationHif Pseudohypoxia

Opdualag

LAG-3 checkpoint inhibitor (anti-LAG-3 monoclonal antibody)

Succinate Lag3 ExhaustionSuccinate Immune Evasion

FDA Approved1 trial

Yervoy

CTLA-4 checkpoint inhibitor (anti-CTLA-4 IgG1κ monoclonal antibody)

Ido1 Kynurenine Treg Ctla4Succinate Immune Evasion

FDA Approved1 trial

Ascorbic Acid (High-dose IV)

TET enzyme cofactor / α-KG-dependent dioxygenase activator

Epigenetic DysregulationOxidative Stress Ros