This tool is for research exploration only. It is not a medical device and does not provide medical advice. Drug candidates, evidence scores, and AI-generated content are not clinical recommendations. Always consult your medical team before making any treatment decisions.

Drug Candidates

14 candidates mapped to SDH-deficient disease pathways

All (38)established (6)clinical trial (5)preclinical (14)theoretical (13)
Decitabine

Dacogen

preclinical

DNA methyltransferase inhibitor (hypomethylating agent)

Epigenetic Dysregulation
All SDH tumors
Evidence Score
62
FDA Approved
Azacitidine

Vidaza

preclinical

DNA methyltransferase inhibitor (hypomethylating agent)

Epigenetic Dysregulation
All SDH tumors
Evidence Score
58
FDA Approved
Olaparib

Lynparza

preclinical

PARP inhibitor (PARP1/2)

Sdh Driven HrdOxidative Stress Ros
All SDH tumors
Evidence Score
58
FDA Approved
Everolimus

Afinitor

preclinical

mTOR inhibitor (rapalog)

Mtor Pi3k Akt
All SDH tumors
Evidence Score
55
FDA Approved
Daporinad (FK866)

APO866

preclinical

NAMPT inhibitor (NAD⁺ biosynthesis inhibitor)

Nad MetabolismOxidative Stress Ros
All SDH tumors
Evidence Score
48
1 trial
Hydroxychloroquine

Plaquenil

preclinical

Autophagy inhibitor (lysosomal alkalinizer)

Autophagy Survival
All SDH tumors
Evidence Score
42
FDA Approved2 trials
Metformin

Glucophage

preclinical

Biguanide / AMPK activator

Mtor Pi3k AktOxidative Stress Ros
All SDH tumors
Evidence Score
40
FDA Approved
DENSPM (N1,N11-Diethylnorspermine)
preclinical

Polyamine analogue / SSAT inducer

Polyamine MetabolismOxidative Stress Ros
PPGL/PCC
Evidence Score
38
Dichloroacetate (DCA)
preclinical

Pyruvate dehydrogenase kinase inhibitor

Hif PseudohypoxiaOxidative Stress Ros
All SDH tumors
Evidence Score
35
Denifanstat

TVB-2640

preclinical

FASN inhibitor (fatty acid synthase inhibitor)

De Novo LipogenesisGlutamine Dependency
All SDH tumors
Evidence Score
35
2 trials
Ceralasertib

AZD6738

preclinical

ATR kinase inhibitor

Atrx Alt Replication Stress
PPGL (ATRX+)
Evidence Score
33
1 trial
Ym155 (Sepantronium Bromide)

YM155, Sepantronium

preclinical

Survivin (BIRC5) transcription inhibitor / IAP inhibitor

Hif Driven Survivin ApoptosisSdh Driven Hrd
All SDH tumors
Evidence Score
31
1 trial
AZD3965
preclinical

MCT1 inhibitor (monocarboxylate transporter 1 inhibitor, SLC16A1)

Succinate Immune Evasion
PPGL/PCC
Evidence Score
30
1 trial
Pevonedistat

TAK-924

preclinical

NAE inhibitor (neddylation inhibitor, NEDD8-activating enzyme inhibitor)

Neddylation
PPGL/PCC
Evidence Score
30