SDH-Engine

Drug Repurposing Engine

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Targeting SDH-deficient GIST, paraganglioma, pheochromocytoma, RCC

This tool is for research exploration only. It is not a medical device and does not provide medical advice. Drug candidates, evidence scores, and AI-generated content are not clinical recommendations. Always consult your medical team before making any treatment decisions.

Drug Candidates

6 candidates mapped to SDH-deficient disease pathways

All (38)established (6)clinical trial (5)preclinical (14)theoretical (13)
Olaparib

Lynparza

preclinical

PARP inhibitor (PARP1/2)

Sdh Driven HrdOxidative Stress Ros
All SDH tumors
Evidence Score
58
FDA Approved
Daporinad (FK866)

APO866

preclinical

NAMPT inhibitor (NAD⁺ biosynthesis inhibitor)

Nad MetabolismOxidative Stress Ros
All SDH tumors
Evidence Score
48
1 trial
Metformin

Glucophage

preclinical

Biguanide / AMPK activator

Mtor Pi3k AktOxidative Stress Ros
All SDH tumors
Evidence Score
40
FDA Approved
DENSPM (N1,N11-Diethylnorspermine)
preclinical

Polyamine analogue / SSAT inducer

Polyamine MetabolismOxidative Stress Ros
PPGL/PCC
Evidence Score
38
Dichloroacetate (DCA)
preclinical

Pyruvate dehydrogenase kinase inhibitor

Hif PseudohypoxiaOxidative Stress Ros
All SDH tumors
Evidence Score
35
Ascorbic Acid (High-dose IV)
theoretical

TET enzyme cofactor / α-KG-dependent dioxygenase activator

Epigenetic DysregulationOxidative Stress Ros
PPGL/PCC
Evidence Score
18