SDH-Engine — Drug Repurposing for SDH-Deficient Diseases

This tool is for research exploration only. It is not a medical device and does not provide medical advice. Drug candidates, evidence scores, and AI-generated content are not clinical recommendations. Always consult your medical team before making any treatment decisions.

Drug Candidates

11 candidates mapped to SDH-deficient disease pathways

All (65)established (7)clinical trial (13)preclinical (13)theoretical (32)

Welireg

HIF-2α inhibitor

Hif Pseudohypoxia

FDA Approved1 trial

Avastin

Anti-VEGF monoclonal antibody

Vegf SignalingHif Pseudohypoxia

STA-9090

HSP90 inhibitor (non-ansamycin resorcinol-based)

Hsp90 Hif Client ChaperoneHif Pseudohypoxia

MLN8237

Aurora A kinase inhibitor (selective, oral)

Aurora Kinase Hif FeedbackHif Pseudohypoxia

MEDI9447

Anti-CD73 monoclonal antibody (immune checkpoint, adenosine pathway)

Hif Cd73 Adenosine ImmunosuppressionHif Pseudohypoxia

Dichloroacetate (DCA)

Pyruvate dehydrogenase kinase inhibitor

Hif PseudohypoxiaOxidative Stress Ros

OSI-906

IGF1R/IR dual kinase inhibitor

Hif Igf2 Igf1r Growth SignalingHif Pseudohypoxia

AB928

Adenosine A2A/A2B receptor antagonist (dual; oral small molecule)

Hif Cd73 Adenosine ImmunosuppressionHif Pseudohypoxia

Hu5F9-G4

Anti-CD47 monoclonal antibody (macrophage phagocytosis-checkpoint inhibitor)

Hif Cd47 Phagocytosis EvasionHif Pseudohypoxia

AMD3100, Mozobil

CXCR4 chemokine receptor antagonist

Hif Cxcr4 Chemokine MetastasisHif Pseudohypoxia

FDA Approved1 trial

WBI-5111

Carbonic anhydrase IX/XII inhibitor (CA9/CA12 selective)

Hif Ca9 Ph RegulationHif Pseudohypoxia