This tool is for research exploration only. It is not a medical device and does not provide medical advice. Drug candidates, evidence scores, and AI-generated content are not clinical recommendations. Always consult your medical team before making any treatment decisions.

Drug Candidates

12 candidates mapped to SDH-deficient disease pathways

All (65)established (7)clinical trial (13)preclinical (13)theoretical (32)
Rogaratinib
clinical trial

Pan-FGFR inhibitor (FGFR1/2/3/4)

Fgfr SignalingEpigenetic Dysregulation
GIST
Evidence Score
76
1 trial
Temozolomide

Temodar, Temodal

clinical trial

Alkylating agent

Epigenetic Dysregulation
PPGL/PCCGIST
Evidence Score
74
FDA Approved1 trial
Tazemetostat

Tazverik

clinical trial

EZH2 inhibitor (PRC2 inhibitor)

Epigenetic Dysregulation
All SDH tumors
Evidence Score
65
FDA Approved1 trial
Decitabine

Dacogen

preclinical

DNA methyltransferase inhibitor (hypomethylating agent)

Epigenetic Dysregulation
All SDH tumors
Evidence Score
62
FDA Approved
Azacitidine

Vidaza

preclinical

DNA methyltransferase inhibitor (hypomethylating agent)

Epigenetic Dysregulation
All SDH tumors
Evidence Score
58
FDA Approved
Birabresib

OTX015, MK-8628

theoretical

BET bromodomain inhibitor (pan-BRD2/3/4)

Epigenetic Dysregulation
GIST
Evidence Score
33
1 trial
Panobinostat

Farydak

theoretical

Pan-HDAC inhibitor

Epigenetic Dysregulation
All SDH tumors
Evidence Score
30
FDA Approved1 trial
Palbociclib

Ibrance

theoretical

CDK4/6 inhibitor

Cdkn2a Cdk46 Cell CycleEpigenetic Dysregulation
GIST
Evidence Score
30
FDA Approved
Enasidenib

Idhifa

theoretical

IDH2 inhibitor

Epigenetic Dysregulation
All SDH tumors
Evidence Score
28
FDA Approved
KB-0742
theoretical

CDK9 inhibitor (selective P-TEFb kinase inhibitor)

Cdk9 Super Enhancer ElongationEpigenetic Dysregulation
GIST
Evidence Score
27
1 trial
CCS1477

Inobrodib

clinical trial

CBP/p300 bromodomain inhibitor

Cbp P300 Hat CoactivatorEpigenetic Dysregulation
All SDH tumors
Evidence Score
27
2 trials
Ascorbic Acid (High-dose IV)
theoretical

TET enzyme cofactor / α-KG-dependent dioxygenase activator

Epigenetic DysregulationOxidative Stress Ros
PPGL/PCC
Evidence Score
18